Perpetual bachelor George Clooney prepped for the Venice Film Festival’s opening night by taking a weeklong, motorcycling man-cation with Bono and Rande Gerber.

Sources tell us that Clooney has cooled things with former female wrestler Stacy Keibler and has been spending time with his friends.

He began his boys-only trip with the U2 singer and husband of Cindy Crawford last week. The trio jumped on matching touring motorcycles and hit the open road, heading through the French Riviera and stopping at Bono’s beachside villa in Eze-sur-Mer. The rocker has famously entertained the likes of Brad Pitt, Angelina Jolie and Robert De Niro at the manse he owns with The Edge.

The three rolled into Monaco, a source said, and partied at legendary nightclub Jimmy’z along the way. They then all headed to Clooney’s place in Lake Como, Italy, where they were joined by supermodel Crawford and actress Evan Rachel Wood.

Clooney floated into Venice yesterday on a boat with Gerber and an entourage for the festival’s opening and premiere of his Oscar hopeful, “The Ides of March.”

His co-star in the political drama, Ryan Gosling, couldn’t make it to Venice because he’s shooting “Gangster Squad” with Sean Penn. Sources say Clooney invited Charlie Rose to the premiere as his special guest.

Meanwhile, Clooney and his ex, Elisabetta Canalis, who split in June after nearly two years, seem to be taking very different paths. While he hits the movie-festival circuit, she has been cast with Chaz Bono and Nancy Grace as a contestant on “Dancing With the Stars.” Keibler was also a “DWTS” contestant.

Clooney’s next stop will be Telluride, Colo., where sources say “Ides” will screen and Clooney will be honored. The buzzy fest keeps its lineup secret till the day before it begins.

Reps did not respond to our requests for comment.