Amigos George Clooney and Rande Gerber will star with their main squeezes, Stacy Keibler and Cindy Crawford, in a short film to launch tequila brand Casamigos. The one-minute flick, we hear, titled “It Could Happen, Please Drink Responsibly,” was directed by Clooney and his “Argo” producing partner Grant Heslov. The starry mini-movie was even shot on location at one of Clooney’s homes, and sources say it’s “loosely based on a true story,” which involves the stars hopping into bed in various odd couplings. Clooney and Gerber were spotted in Dallas on Monday night at a margarita mecca called the Iron Cactus as part of a national tour they’re on to meet with spirits executives. Gerber’s also about to nationally launch Caliche Rum with Puerto Rican distiller Roberto Serralles. Clooney — unveiled yesterday as a presenter at Sunday’s Golden Globe Awards — and Gerber are said to have been privately creating their own house tequila for years with a master distiller after they both built homes in Mexico. Upon perfecting the potion, the pair decided to make it available for the masses.