“Avatar” star Zoe Saldana and “Sexiest Man Alive” Bradley Cooper have broken up again, Page Six has exclusively learned.

We’re told that the Queens-raised beauty and “The Hangover” star Cooper split up before the holidays, which they had planned to spend together.

Saldana, 34, and Cooper, 37, originally dated for three months after filming “The Words” together and split in March last year, but they reconciled in September.

A source told us, “Zoe had planned to spend the holidays with Bradley and his family in Europe. They all were going to Paris, but things didn’t work out between them. Zoe spent New Year’s Eve with friends in Miami.”

Things are believed to have fizzled out between the pair while Cooper has been busy promoting his movie “Silver Linings Playbook,” which co-stars Jennifer Lawrence and is getting serious awards buzz.

Handsome Cooper, who was voted People’s “Sexiest Man Alive” last year before the honor was bestowed on Channing Tatum, is currently believed to be in Prague shooting a commercial.

Meanwhile Saldana, who has been shooting “Star Trek” and “Blood Ties” with Mila Kunis, celebrated the countdown to 2013 in South Beach. She enjoyed a private dinner with family and friends at Catch Miami, before counting down the new year poolside at the James Royal Palm on Collins Avenue. Saldana was later seen dancing with friends to music from female DJ duo Nervo.

A witness added, “If Zoe was upset over the split with Bradley, she didn’t show it.”

Saldana, who split from fiancé and love of 10 years Keith Britton in November 2011, was joined by supermodel Karolina Kurkova, the Miami Heat’s Chris Bosh and Dwyane Wade, along with their partners Adrienne Bosh and Gabrielle Union.

Reps for both Cooper and Saldana didn’t get back to us last night.